Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NT5C (Q8TCD5) - Overview - Molecular Target Synopsis

Protein


NT5C, 5'(3')-deoxyribonucleotidase, cytosolic type
Enzyme Classification 3.1.3.-
UniProt Q8TCD5

Also Known as NT5C_HUMAN, NT5C, DNT1, UMPH2

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP. Homodimer.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: NT5C is active in the following subcellular-locations: cytoplasm.
GO terms: NT5C is active in the following subcellular-locations: cytoplasm, cytosol, extracellular exosome, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NT5C has gain in 6 cell-lines, loss in 0 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: KM12, CAKI_1, A549

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SCC-9, HCC1359, JHH-4

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, K562

(see details)

3D Structures


For NT5C there are:
4 structures (8 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis