Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACTL9 (Q8TC94) - Overview - Molecular Target Synopsis

Protein


ACTL9, Actin-like protein 9
UniProt Q8TC94

Also Known as ACTL9_HUMAN, ACTL9, ACTL7C

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
439ENSG00000181786ENST00000324436ENSP00000316674
416Q8TC94-1

Sub-cellular localization


UniProt: ACTL9 is active in the following subcellular-locations: cytoplasm, cytoskeleton.
GO terms: ACTL9 is active in the following subcellular-locations: cytoplasm, cytoskeleton.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACTL9 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 1005 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to ACTL9 there are:
77 structures (246 chains) solved
67 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ACTL9 has been screened with compounds ( bioactivities). (see details)