Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FAM110B (Q8TC76) - Overview - Molecular Target Synopsis

Protein


FAM110B, Protein FAM110B
UniProt Q8TC76

Also Known as F110B_HUMAN, FAM110B, C8orf72

May be involved in tumor progression.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
476ENSG00000169122ENST00000361488ENSP00000355204
370Q8TC76-1

Sub-cellular localization


UniProt: FAM110B is active in the following subcellular-locations: centrosome, cytoplasm, cytoskeleton, microtubule organizing center.
GO terms: FAM110B is active in the following subcellular-locations: cytosol, microtubule organizing center, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FAM110B has gain in 8 cell-lines, loss in 5 cell-lines and no signal in 991 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, UO_31, NCI_H226

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-134-VI, COR-L47, NCI-H889

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, HMEC, NHLF

(see details)

RNA Interference


FAM110B was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)