Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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Germline Genetics

PIWIL2 (Q8TC59) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed8
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria6


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
3O7X_D Piwi-like protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 62.9 25.1 Yes No
2 empty 1.96 60.4 21.7 No No
3 empty 2.64 65 14.4 No No
4 empty 1.58 60.5 11.3 No No
5 empty 2.2 52 12.1 No No
6 empty 2.02 52.3 11.3 No No
7 empty 2.48 71.4 6.3 No No
8 empty 2 52.1 8.5 No No
9 empty 2.91 51.3 7.8 No No
10 empty 2.81 75.5 5.4 No No
3O7X_C Piwi-like protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 61.8 26.8 Yes No
2 empty 1.96 56.7 20.1 No No
3 empty 1.9 66 9.9 No No
4 empty 2.57 55.5 14.6 No No
5 empty 2.16 47.6 13.4 No No
6 empty 2.15 56.9 14.9 No No
7 empty 2.58 71.3 6.1 No No
8 empty 2.41 70 7.4 No No
9 empty 2.81 66.4 6.1 No No
10 empty 2.08 81.3 5.8 No No
3QIR_A Piwi-like protein 2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.9 56.6 23.6 No No
2 empty 1.77 61.5 29 No No
3 empty 2.43 60.3 14.5 No No
4 empty 2.01 56.3 14.5 No No
5 empty 1.66 49.7 9.8 No No
6 empty 1.87 65 6.2 No No
7 empty 2.51 78.3 6.3 No No
8 empty 2.26 60.1 7.2 No No
9 empty 2.08 62 6.8 No No
10 empty 2.95 52.4 7.5 No No
3QIR_C Piwi-like protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.68 60.7 26.3 Yes No
2 empty 1.82 61.4 19.6 No No
3 empty 2.09 61.4 11.8 No No
4 empty 1.88 64.4 9.7 No No
5 empty 2.49 57.8 14.6 No No
6 empty 2.73 65 12.8 No No
7 empty 1.87 60.6 11.4 No No
8 empty 1.85 53.6 7.6 No No
9 empty 2.31 78.7 0 No No
10 empty 2.59 65.9 6 No No
3O7X_B Piwi-like protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 61.4 39.2 Yes No
2 empty 1.72 63 11.1 No No
3 empty 2.37 49.4 11.3 No No
4 empty 2.15 54.3 14.9 No No
5 empty 2.24 65.5 8.8 No No
6 empty 2.32 64.7 9.8 No No
7 empty 2.5 71.6 8.1 No No
8 empty 2.84 60.2 6.3 No No
9 empty 2.81 51.4 7.7 No No
10 empty 2.38 65.3 5.9 No No
3QIR_D Piwi-like protein 2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 59.7 23.9 No No
2 empty 1.87 59.9 25.1 No No
3 empty 2.11 59.1 13.6 No No
4 empty 2.48 59.3 11.4 No No
5 empty 2.62 53.3 11.6 No No
6 empty 2.32 60.9 7.8 No No
7 empty 1.6 58.5 11.9 No No
8 empty 2.91 55.5 7.4 No No
9 empty 1.76 63.1 6.6 No No
10 empty 2.44 72.6 6.6 No No
3O7X_A Piwi-like protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 62.2 28.1 Yes No
2 empty 2.11 62 25.2 No No
3 empty 1.96 60.1 12.5 No No
4 empty 2.49 52 14.8 No No
5 empty 2.23 58 15 No No
6 empty 2.55 76 5.7 No No
7 empty 1.99 47.2 9.3 No No
8 empty 2.27 69.8 6.5 No No
9 empty 3.19 61.2 7.2 No No
10 empty 2.49 55.4 9.5 No No
3QIR_B Piwi-like protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.22 61.9 24.7 Yes No
2 empty 1.91 62.5 24.4 No No
3 empty 2.1 54.9 14.1 No No
4 empty 1.91 57.6 14.5 No No
5 empty 2.28 67.5 9.3 No No
6 empty 2.34 58 10 No No
7 empty 2.42 68.6 7.4 No No
8 empty 1.44 64.6 8.7 No No
9 empty 2.64 60.3 6.2 No No
10 empty 2.21 52.9 6 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed4
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria3

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
3O7X_A (3640980) Piwi-like protein 2 PFAM, PFAM, PFAM PAZ 2.92Å Yes No
3O7X_B (4216683) Piwi-like protein 2 UNMATCHED, UNMATCHED, UNMATCHED 3O7X HOMO 2.92Å Yes No
3O7X_C (4216683) Piwi-like protein 2 UNMATCHED, UNMATCHED, UNMATCHED 3O7X HOMO 2.92Å Yes No
3QIR_B (4263642) Piwi-like protein 2 UNMATCHED, UNMATCHED, UNMATCHED 3QIR HOMO 2.45Å Yes No
3QIR_C (4263642) Piwi-like protein 2 UNMATCHED, UNMATCHED, UNMATCHED 3QIR HOMO 2.45Å Yes No
3QIR_A (3690087) Piwi-like protein 2 PFAM, PFAM, PFAM PAZ 2.45Å No No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


PIWIL2 is involved in 11 interactions in the network.


Druggability
Overall Druggability Percentile: 84.80
Druggability for Cancer Therapeutics: 89.86
Druggability for Other Therapeutics: 92.84
Cancer-Associated
Cancer-associated percentile : 69.92
Network Articulation Point
Is PIWIL2 critical for communication in the network?


Detailed Graph Legend:Help