Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TRMT10A (Q8TBZ6) - Overview - Molecular Target Synopsis

Protein


TRMT10A, tRNA methyltransferase 10 homolog A
Enzyme Classification 2.1.1.221
UniProt Q8TBZ6

Also Known as TM10A_HUMAN, TRMT10A, RG9MTD2

S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678, PubMed:25053765). Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678). Interacts with tRNA.

4FMW
CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAIN OF HUMAN RNA (GUANINE-9- ) METHYLTRANSFERASE DOMAIN CONTAINING PROTEIN 2
RCSB/PDB
Inspect Structure
See all 3D Structures for TRMT10A

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TRMT10A is active in the following subcellular-locations: nucleolus, nucleus.
GO terms: TRMT10A is active in the following subcellular-locations: actin cytoskeleton, cytosol, extracellular exosome, mitochondrion, nucleolus, nucleoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TRMT10A has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC1395, MFM-223, SU-DHL-5

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: MCF-7, SK-N-SH, HSMM

(see details)

3D Structures


For TRMT10A there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis