Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC7A14 (Q8TBB6) - Overview - Molecular Target Synopsis

Protein


SLC7A14, Probable cationic amino acid transporter
UniProt Q8TBB6

Also Known as S7A14_HUMAN, SLC7A14, KIAA1613

May be involved in arginine transport.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
771ENSG00000013293ENST00000231706ENSP00000231706Q8TBB6-1

Sub-cellular localization


UniProt: SLC7A14 is active in the following subcellular-locations: lysosome membrane.
GO terms: SLC7A14 is active in the following subcellular-locations: integral component of membrane, lysosomal membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC7A14 has gain in 16 cell-lines, loss in 0 cell-lines and no signal in 989 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, ACHN, SN12C

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-N-FI, NCI-H187, NCI-H2171

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: hMSC-AT, SK-N-SH, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to SLC7A14 there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

SLC7A14 is solved in complex with the approved drug(s):

CLR/CHOLESTEROL (6F34_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SLC7A14 has been screened with compounds ( bioactivities). (see details)