Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GDAP1 (Q8TB36) - Overview - Molecular Target Synopsis

Protein


GDAP1, Ganglioside-induced differentiation-associated protein 1
UniProt Q8TB36

Also Known as GDAP1_HUMAN, GDAP1

Regulates the mitochondrial network by promoting mitochondrial fission. Homodimer.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: GDAP1 is active in the following subcellular-locations: cytoplasm, mitochondrion outer membrane.
GO terms: GDAP1 is active in the following subcellular-locations: cytosol, integral component of mitochondrial outer membrane, membrane, mitochondrion, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GDAP1 has gain in 14 cell-lines, loss in 2 cell-lines and no signal in 989 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: LOXIMVI, UACC_257, MDA_N

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC2911, NCI-H1155, HCC12

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: MCF-7, SK-N-SH_RA, GM12878

(see details)