Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RIN3 (Q8TB24) - Overview - Molecular Target Synopsis

Protein


RIN3, Ras and Rab interactor 3
UniProt Q8TB24

Also Known as RIN3_HUMAN, RIN3

Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function. Interacts with CD2AP, RAB5B, RAB31 and BIN1.

4WCI
10 RESIDUE FRAGMENT OF
RAS AND RAB INTERACTOR 3
IN THE STRUCTURE OF
CRYSTAL STRUCTURE OF THE 1ST SH3 DOMAIN FROM HUMAN CD2AP (CMS) IN COMPLEX WITH A PROLINE-RICH PEPTIDE (AA 378-393) FROM HUMAN RIN3
RCSB/PDB
Inspect Structure
See all 3D Structures for RIN3

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RIN3 is active in the following subcellular-locations: cytoplasm, cytoplasmic vesicle, early endosome.
GO terms: RIN3 is active in the following subcellular-locations: cytoplasmic vesicle, cytosol, early endosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RIN3 has gain in 5 cell-lines, loss in 2 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H226, MDA_N, NCI_H322M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HNT-34, KG-1, UKE-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: CD14-positive monocyte, CD34-positive mobilized cell, HSMM

(see details)

3D Structures


For RIN3 there are:
2 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis