Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

UHMK1 (Q8TAS1) - Domains And Structures - Molecular Target Synopsis

Click Here to View Molecular Target 3D Synopsis

Select a homology cutoff:
Structural Sequence Similarity Matches
Domains Covered Gene Name (Uniprot) Solved in Complex with Organism PDB Chain Identity E-Value Resolution Ligands Release Date
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 5A54_B 35.9 5.0E-11 2.63Å 5PW 2016-06-29
Protein kinase domain (41%) (view alignment) DYRK2 (Q92630) - HUMAN 3KVW_A 38.26 1.0E-12 2.28Å IRB 2010-01-05
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6A1F_A 35.9 4.0E-11 1.5Å 9OF PGE 2018-10-03
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 2VX3_A 35.9 5.0E-11 2.4Å D15 2008-09-16
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIS_A 35.9 5.0E-11 2.36Å B6N 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 4YLJ_C 35.9 5.0E-11 2.58Å 4E1 2015-03-25
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIS_B 35.9 5.0E-11 2.36Å B6N 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIP_A 35.9 5.0E-11 2.55Å B7B 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 4NCT_C 35.9 5.0E-11 2.597Å 2K2 2015-04-01
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIV_D 35.9 5.0E-11 2.68Å B6Q 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 5A4E_D 35.9 5.0E-11 2.68Å 7QQ 2016-06-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6S17_A 35.9 5.0E-11 1.1Å KQK 2019-06-26
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 4NCT_A 35.9 5.0E-11 2.597Å 2K2 2015-04-01
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 3ANR_B 35.9 5.0E-11 2.6Å HRM 2010-11-10
Protein kinase domain (41%) (view alignment) DYRK2 (Q92630) - HUMAN 5LXD_A 38.26 1.0E-12 2.58Å 7A7 2016-10-26
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 4MQ2_D 35.9 5.0E-11 2.8Å 2C4 2013-12-11
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) CRB2 (Q5IJ48) HUMAN 2WO6_B 35.9 5.0E-11 2.5Å D15 2009-08-18
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EJ4_D 35.9 5.0E-11 2.88Å B7W 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6S11_A 35.9 5.0E-11 2.44Å KQE 2019-06-26
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIF_D 35.9 5.0E-11 1.93Å B5T 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK2 (Q92630) - HUMAN 5ZTN_B 38.26 1.0E-12 2.496Å CUR 2018-07-18
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EJ4_C 35.9 5.0E-11 2.88Å B7W 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIS_D 35.9 5.0E-11 2.36Å B6N 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 5A54_A 35.9 5.0E-11 2.63Å 5PW 2016-06-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIR_D 35.9 5.0E-11 2.4Å B6H 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6A1G_B 35.9 4.0E-11 2.15Å 9OL 2018-10-03
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) CRB2 (Q5IJ48) HUMAN 2WO6_A 35.9 5.0E-11 2.5Å D15 2009-08-18
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6S14_A 35.9 5.0E-11 1.05Å KQW 2019-06-26
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 4YLK_A 35.9 5.0E-11 1.4Å 4E2 2015-03-25
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 2VX3_D 35.9 5.0E-11 2.4Å D15 2008-09-16
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 5AIK_D 35.9 5.0E-11 2.7Å AWR 2015-02-25
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 4MQ2_C 35.9 5.0E-11 2.8Å 2C4 2013-12-11
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIQ_C 35.9 5.0E-11 2.3Å B6Z 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIJ_A 35.9 5.0E-11 2.42Å B5Z 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 4YU2_B 35.9 5.0E-11 2.9Å 4H5 2015-03-25
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 4NCT_B 35.9 5.0E-11 2.597Å 2K2 2015-04-01
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 4MQ2_B 35.9 5.0E-11 2.8Å 2C4 2013-12-11
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 5A4L_B 35.9 5.0E-11 2.73Å ZC3 2016-06-29
Protein kinase domain (41%) (view alignment) DYRK2 (Q92630) - HUMAN 5LXD_B 38.26 1.0E-12 2.58Å 7A7 2016-10-26
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 5A4L_C 35.9 5.0E-11 2.73Å ZC3 2016-06-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6S1H_A 35.9 5.0E-11 1.05Å KQZ 2019-06-26
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 4NCT_D 35.9 5.0E-11 2.597Å 2K2 2015-04-01
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIQ_B 35.9 5.0E-11 2.3Å B6Z 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6S1J_A 35.9 5.0E-11 1.41Å KRK 2019-06-26
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIS_C 35.9 5.0E-11 2.36Å B6N 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 3ANR_A 35.9 5.0E-11 2.6Å HRM 2010-11-10
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 4MQ2_A 35.9 5.0E-11 2.8Å 2C4 2013-12-11
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 4AZE_A 35.9 5.0E-11 3.15Å 3RA 2012-09-05
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIL_D 35.9 5.0E-11 2.46Å B6B 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 4AZE_B 35.9 5.0E-11 3.15Å 3RA 2012-09-05
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIL_B 35.9 5.0E-11 2.46Å B6B 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 5A4Q_A 35.9 5.0E-11 2.37Å Y3L 2016-06-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIV_C 35.9 5.0E-11 2.68Å B6Q 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 4MQ1_A 35.9 5.0E-11 2.35Å 2C3 2013-12-11
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 4MQ1_B 35.9 5.0E-11 2.35Å 2C3 2013-12-11
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 5A4Q_D 35.9 5.0E-11 2.37Å Y3L 2016-06-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 3ANQ_B 35.9 5.0E-11 2.6Å EHB 2010-11-10
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 4YLJ_A 35.9 5.0E-11 2.58Å 4E1 2015-03-25
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIQ_A 35.9 5.0E-11 2.3Å B6Z 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 4MQ1_D 35.9 5.0E-11 2.35Å 2C3 2013-12-11
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 5A4T_D 35.9 5.0E-11 2.05Å AJG 2016-06-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 5AIK_C 35.9 5.0E-11 2.7Å AWR 2015-02-25
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIF_B 35.9 5.0E-11 1.93Å B5T 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 2VX3_B 35.9 5.0E-11 2.4Å D15 2008-09-16
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 4YU2_C 35.9 5.0E-11 2.9Å 4H5 2015-03-25
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 5AIK_B 35.9 5.0E-11 2.7Å AWR 2015-02-25
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 5A3X_A 35.9 5.0E-11 2.26Å QIV 2016-06-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIJ_C 35.9 5.0E-11 2.42Å B5Z 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIR_C 35.9 5.0E-11 2.4Å B6H 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 4YU2_A 35.9 5.0E-11 2.9Å 4H5 2015-03-25
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIV_B 35.9 5.0E-11 2.68Å B6Q 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIP_D 35.9 5.0E-11 2.55Å B7B 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 5A4E_B 35.9 5.0E-11 2.68Å 7QQ 2016-06-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIL_A 35.9 5.0E-11 2.46Å B6B 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 5A4L_D 35.9 5.0E-11 2.73Å ZC3 2016-06-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 4YLJ_D 35.9 5.0E-11 2.58Å 4E1 2015-03-25
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIR_B 35.9 5.0E-11 2.4Å B6H 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIF_C 35.9 5.0E-11 1.93Å B5T 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIP_C 35.9 5.0E-11 2.55Å B7B 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 3ANQ_A 35.9 5.0E-11 2.6Å EHB 2010-11-10
Protein kinase domain (41%) (view alignment) DYRK2 (Q92630) - HUMAN 5LXC_A 38.26 1.0E-12 2.15Å 7AA 2016-10-26
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 4MQ1_C 35.9 5.0E-11 2.35Å 2C3 2013-12-11
Protein kinase domain (41%) (view alignment) DYRK2 (Q92630) - HUMAN 3K2L_A 38.26 1.0E-12 2.36Å - 2009-10-13
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 3ANQ_C 35.9 5.0E-11 2.6Å EHB 2010-11-10
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 5A54_C 35.9 5.0E-11 2.63Å 5PW 2016-06-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6S1I_B 35.9 5.0E-11 2.38Å KR8 2019-06-26
Protein kinase domain (41%) (view alignment) DYRK2 (Q92630) - HUMAN 4AZF_A 38.26 2.0E-12 2.55Å 3RA 2012-09-05
Protein kinase domain (41%) (view alignment) DYRK3 (O43781) - HUMAN 5Y86_A 35.65 2.0E-12 1.85Å HRM 2018-05-02
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 3ANQ_D 35.9 5.0E-11 2.6Å EHB 2010-11-10
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 4YLL_A 35.9 5.0E-11 1.4Å 4E3 2015-03-25
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 5A4T_B 35.9 5.0E-11 2.05Å AJG 2016-06-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 5A4T_A 35.9 5.0E-11 2.05Å AJG 2016-06-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 2VX3_C 35.9 5.0E-11 2.4Å D15 2008-09-16
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6S11_B 35.9 5.0E-11 2.44Å KQE 2019-06-26
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 5A4Q_C 35.9 5.0E-11 2.37Å Y3L 2016-06-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 4AZE_C 35.9 5.0E-11 3.15Å 3RA 2012-09-05
Protein kinase domain (41%) (view alignment) DYRK2 (Q92630) - HUMAN 5LXC_B 38.26 1.0E-12 2.15Å 7AA 2016-10-26
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 5A4E_A 35.9 5.0E-11 2.68Å 7QQ 2016-06-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIJ_B 35.9 5.0E-11 2.42Å B5Z 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 5A4L_A 35.9 5.0E-11 2.73Å ZC3 2016-06-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6S1I_C 35.9 5.0E-11 2.38Å KR8 2019-06-26
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIF_A 35.9 5.0E-11 1.93Å B5T 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 5A4T_C 35.9 5.0E-11 2.05Å AJG 2016-06-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIP_B 35.9 5.0E-11 2.55Å B7B 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6S1I_A 35.9 5.0E-11 2.38Å KR8 2019-06-26
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 5A4E_C 35.9 5.0E-11 2.68Å 7QQ 2016-06-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIQ_D 35.9 5.0E-11 2.3Å B6Z 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6A1G_A 35.9 4.0E-11 2.15Å 9OL 2018-10-03
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 5A4Q_B 35.9 5.0E-11 2.37Å Y3L 2016-06-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 3ANR_C 35.9 5.0E-11 2.6Å HRM 2010-11-10
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 5A3X_B 35.9 5.0E-11 2.26Å QIV 2016-06-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 4YU2_D 35.9 5.0E-11 2.9Å 4H5 2015-03-25
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 5A3X_D 35.9 5.0E-11 2.26Å QIV 2016-06-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 5A3X_C 35.9 5.0E-11 2.26Å QIV 2016-06-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 5AIK_A 35.9 5.0E-11 2.7Å AWR 2015-02-25
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIR_A 35.9 5.0E-11 2.4Å B6H 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIL_C 35.9 5.0E-11 2.46Å - 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 3ANR_D 35.9 5.0E-11 2.6Å HRM 2010-11-10
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EJ4_A 35.9 5.0E-11 2.88Å B7W 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6S1B_A 35.9 5.0E-11 1.3Å KRQ 2019-06-26
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6S1I_D 35.9 5.0E-11 2.38Å KR8 2019-06-26
Protein kinase domain (41%) (view alignment) DYRK2 (Q92630) - HUMAN 5ZTN_A 38.26 1.0E-12 2.496Å CUR 2018-07-18
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 5A54_D 35.9 5.0E-11 2.63Å 5PW 2016-06-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EJ4_B 35.9 5.0E-11 2.88Å B7W 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 4YLJ_B 35.9 5.0E-11 2.58Å 4E1 2015-03-25
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIJ_D 35.9 5.0E-11 2.42Å B5Z 2018-08-29
Protein kinase domain (41%) (view alignment) DYRK1A (Q13627) - HUMAN 6EIV_A 35.9 5.0E-11 2.68Å B6Q 2018-08-29