Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RHEBL1 (Q8TAI7) - Overview - Molecular Target Synopsis

Protein


RHEBL1, GTPase RhebL1
UniProt Q8TAI7

Also Known as REBL1_HUMAN, RHEBL1

Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2. Interacts with MTOR.

3OES
CRYSTAL STRUCTURE OF THE SMALL GTPASE RHEBL1
RCSB/PDB
Inspect Structure
See all 3D Structures for RHEBL1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RHEBL1 is active in the following subcellular-locations: cytoplasm, endomembrane system.
GO terms: RHEBL1 is active in the following subcellular-locations: cytoplasm, endomembrane system, membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RHEBL1 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCI-M2, SK-N-FI, SR-786

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, NHLF, HSMM

(see details)

3D Structures


For RHEBL1 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RHEBL1 has been screened with compounds ( bioactivities). (see details)