Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

rpoB (Q8RQE9) - Overview - Molecular Target Synopsis

Protein


rpoB, DNA-directed RNA polymerase subunit beta
Enzyme Classification 2.7.7.6
UniProt Q8RQE9

Also Known as RPOB_THET8, rpoB

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

6OY6
X-RAY CRYSTAL STRUCTURE OF A BACTERIAL REITERATIVE TRANSCRIPTION COMPLEX OF PYRG PROMOTER AT 5 MIN
RCSB/PDB
Inspect Structure
See all 3D Structures for rpoB

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1119Q8RQE9-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project rpoB has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For rpoB there are:
51 structures (92 chains) solved
9 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

rpoB is solved in complex with the approved drug(s):

RPT/RIFAPENTINE (2A69_C, 2A69_M),
RBT/RIFABUTIN (2A68_C, 2A68_M).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


rpoB has been screened with compounds ( bioactivities). (see details)