Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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Germline Genetics

rpoZ (Q8RQE7) - Overview - Molecular Target Synopsis

Protein


rpoZ, DNA-directed RNA polymerase subunit omega
Enzyme Classification 2.7.7.6
UniProt Q8RQE7

Also Known as RPOZ_THET8, rpoZ

Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

6ASG
CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS RNA POLYMERASE CORE ENZYME
RCSB/PDB
Inspect Structure
See all 3D Structures for rpoZ

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
99Q8RQE7-1, Q72ID6-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project rpoZ has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For rpoZ there are:
44 structures (72 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis