Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MFSD8 (Q8NHS3) - Overview - Molecular Target Synopsis

Protein


MFSD8, Major facilitator superfamily domain-containing protein 8
UniProt Q8NHS3

Also Known as MFSD8_HUMAN, MFSD8, CLN7

May be a carrier that transport small solutes by using chemiosmotic ion gradients.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MFSD8 is active in the following subcellular-locations: lysosome membrane.
GO terms: MFSD8 is active in the following subcellular-locations: integral component of membrane, intracellular membrane-bounded organelle, lysosomal membrane, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MFSD8 has gain in 0 cell-lines, loss in 6 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: OVCAR_8, MDA_MB_231, HCT_15

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OVCAR-8, NCI-H1568, MKN-7

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, MCF-7

(see details)