Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NEK11 (Q8NG66) - Overview - Molecular Target Synopsis

Protein


NEK11, Serine/threonine-protein kinase Nek11
Enzyme Classification 2.7.11.1
UniProt Q8NG66

Also Known as NEK11_HUMAN, NEK11

Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. Interacts with isoform 1 of NEK2.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: NEK11 is active in the following subcellular-locations: nucleolus, nucleus.
GO terms: NEK11 is active in the following subcellular-locations: nucleolus, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NEK11 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: TK_10, T47D, LOXIMVI

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC12, LN-18, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, SK-N-SH, HMEC

(see details)

RNA Interference


NEK11 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: CAL51, CAOV3. (see details)

3D Structures


At greater than 35% identity similarity to NEK11 there are:
34 structures (36 chains) solved
30 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


NEK11 has been screened with 247 compounds (418 bioactivities), 3 compounds have bioactivities that show binding affinity of <= 500nM (3 bioactivities). (see details)