Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABHD11 (Q8NFV4) - Overview - Molecular Target Synopsis

Protein


ABHD11, Protein ABHD11
Enzyme Classification 3.-.-.-
UniProt Q8NFV4

Also Known as ABHDB_HUMAN, ABHD11, WBSCR21

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: ABHD11 is active in the following subcellular-locations: mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABHD11 has gain in 1 cell-lines, loss in 3 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HCC_2998, HCT_15, KM12

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DV-90, OVSAHO, LS 174T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, HMEC

(see details)


Screening and Chemistry


ABHD11 has been screened with 4 compounds (4 bioactivities), 3 compounds have bioactivities that show binding affinity of <= 500nM (3 bioactivities). (see details)