Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ADCY4 (Q8NFM4) - Overview - Molecular Target Synopsis

Protein


ADCY4, Adenylate cyclase type 4
Enzyme Classification 4.6.1.1
UniProt Q8NFM4

Also Known as ADCY4_HUMAN, ADCY4

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ADCY4 is active in the following subcellular-locations: cell membrane, cytoplasm.
GO terms: ADCY4 is active in the following subcellular-locations: cytoplasm, dendrite, integral component of plasma membrane, membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ADCY4 has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HCT_116, MDA_N, SR

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: UKE-1, Hs 839.T, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HUVEC, SK-N-SH, NHLF

(see details)

3D Structures


At greater than 75% identity similarity to ADCY4 there are:
17 structures (18 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ADCY4 has been screened with 49 compounds (52 bioactivities), 23 compounds have bioactivities that show binding affinity of <= 500nM (24 bioactivities). (see details)