Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ANKK1 (Q8NFD2) - Overview - Molecular Target Synopsis

Protein


ANKK1, Ankyrin repeat and protein kinase domain-containing protein 1
Enzyme Classification 2.7.11.1
UniProt Q8NFD2

Also Known as ANKK1_HUMAN, ANKK1, PKK2, SGK288

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
765ENSG00000170209ENST00000303941ENSP00000306678Q8NFD2-1
58ENSG00000170209ENST00000542948ENSP00000445810

Gene Copy Number Variation


In COSMIC - Cell Lines Project ANKK1 has gain in 4 cell-lines, loss in 7 cell-lines and no signal in 994 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, SK-N-FI

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


ANKK1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: OVAS, OVTOKO. (see details)

3D Structures


At greater than 50% identity similarity to ANKK1 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ANKK1 has been screened with 96 compounds (134 bioactivities), 9 compounds have bioactivities that show binding affinity of <= 500nM (15 bioactivities). (see details)