Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

ANKK1 (Q8NFD2) - Overview - Molecular Target Synopsis


ANKK1, Ankyrin repeat and protein kinase domain-containing protein 1
Enzyme Classification
UniProt Q8NFD2

Also Known as ANKK1_HUMAN, ANKK1, PKK2, SGK288

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Gene Copy Number Variation

In COSMIC - Cell Lines Project ANKK1 has gain in 4 cell-lines, loss in 7 cell-lines and no signal in 994 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, SK-N-FI

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference

ANKK1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: OVAS, OVTOKO. (see details)

3D Structures

At greater than 50% identity similarity to ANKK1 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

ANKK1 has been screened with 96 compounds (134 bioactivities), 9 compounds have bioactivities that show binding affinity of <= 500nM (15 bioactivities). (see details)