Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

CSNK2A3 (Q8NEV1) - Overview - Molecular Target Synopsis


CSNK2A3, Casein kinase II subunit alpha 3
Enzyme Classification
UniProt Q8NEV1

Also Known as CSK23_HUMAN, CSNK2A3, CSNK2A1P

Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression. Heterotetramer composed of two catalytic subunits (alpha chain and/or alpha' chain) and two regulatory subunits (beta chains) (By similarity). Interacts with PML.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

GO terms: CSNK2A3 is active in the following subcellular-locations: nucleoplasm.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project CSNK2A3 has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: WSU-FSCCL, HCC38, TK

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, HMEC

(see details)

3D Structures

At greater than 90% identity similarity to CSNK2A3 there are:
154 structures (238 chains) solved
135 are solved in complex with at least one small molecule ligand
3 are solved with an approved drug

CSNK2A3 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

CSNK2A3 has been screened with compounds ( bioactivities). (see details)