Molecular Target Synopsis
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TRPV3 (Q8NET8) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 08/10/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 08/10/2019)


Chains assessed28
Chains with at least one site assessed as druggable using the strict criteria28
Chains with at least one site assessed as druggable using the relaxed criteria28


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
6MHV_B Transient receptor potential cation channel subfamily V member 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.83 71.4 46.6 Yes Yes
2 empty 2.06 67.5 48.4 No No
3 empty 1.75 68.1 35.2 No No
4 empty 1.59 62.5 32.1 No No
5 empty 2.04 65.2 20.7 No No
6 empty 1.87 72 18.8 No No
7 empty .95 61.4 19.7 No No
8 empty 2.11 77.9 16.3 No No
9 empty 1.39 77.7 16.6 No No
10 empty 2.02 63 19.9 No No
6MHO_B Transient receptor potential cation channel subfamily V member 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.59 72.5 39.1 Yes Yes
2 empty 2.09 62 43 No No
3 empty 1.9 68 38.9 No No
4 empty 1.32 66.1 28.8 No No
5 empty 1.78 71.3 24.1 No No
6 empty 2.02 70.6 30.9 No No
7 empty 1.32 71.9 20.1 No No
8 empty 1.51 78.3 16.3 No No
9 empty .93 64 21.1 No No
10 empty 2.01 68.9 12.3 No No
6OT2_D Transient receptor potential cation channel subfamily V member 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 71.1 42.2 Yes Yes
2 empty 1.88 67.4 51 No No
3 empty 1.67 63.7 53.7 No No
4 empty 1.3 69.5 25.1 No No
5 empty 1.67 67.4 22.3 No No
6 empty .87 64.3 23.9 No No
7 empty 2.01 77.2 19.2 No No
8 empty 1.98 72 18.9 No No
9 empty 1.77 61.2 17.3 No No
10 empty 1.66 70.5 12 No No
6MHV_D Transient receptor potential cation channel subfamily V member 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.85 72.1 46.3 Yes Yes
2 empty 1.94 68.9 45.4 No No
3 empty 2.07 61.5 36.3 No No
4 empty 1.72 69.5 34.2 No No
5 empty 1.69 63.2 30.8 No No
6 empty 1.74 67.6 23.9 No No
7 empty 1.95 63.9 21 No No
8 empty 2.08 79.3 17.6 No No
9 empty .95 62.5 20.2 No No
10 empty 1.41 75.5 17.4 No No
6MHW_A Transient receptor potential cation channel subfamily V member 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.22 69.4 66.6 Yes Yes
2 empty 1.52 64.8 29.1 No No
3 empty 1.49 66.3 26.1 No No
4 empty 1.17 68.2 27.6 No No
5 empty 1.94 66.1 21.6 No No
6 empty 1.79 79.2 13.8 No No
7 empty .92 62.7 20 No No
8 empty 1.8 68.6 18.8 No No
9 empty 2.01 76.3 18.8 No No
10 empty 2.26 66.3 19.4 No No
6MHV_A Transient receptor potential cation channel subfamily V member 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.69 70.6 45.4 Yes Yes
2 empty 1.98 72.7 34.5 No No
3 empty 2.05 61.7 37.9 No No
4 empty 1.7 64.7 31.1 No No
5 empty 1.78 64.5 29.3 No No
6 empty 1.95 66.8 20.3 No No
7 empty 1.73 70.4 15.1 No No
8 empty 1.11 62.8 21 No No
9 empty 1.41 76.3 17.7 No No
10 empty 2.09 75.3 17 No No
6OT5_C Transient receptor potential cation channel subfamily V member 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.74 70 57.4 Yes Yes
2 empty 1.91 68.6 49.9 No No
3 bound 2.01 68.4 36.3 No No
4 empty 1.98 62 31.8 No No
5 empty 1.31 68.9 22.9 No No
6 empty 1.86 66.1 26.5 No No
7 empty 1.8 65.5 20.1 No No
8 empty 1.96 65.2 14.9 No No
9 empty .89 63.9 20.4 No No
10 empty 1.5 66.6 18.9 No No
6MHX_D Transient receptor potential cation channel subfamily V member 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.95 71.6 52.9 Yes Yes
2 empty 1.96 67 36 No No
3 empty 1.87 65.4 30.7 No No
4 empty 1.6 76 30.2 No No
5 empty 1.39 65.3 24.1 No No
6 empty 1.82 65 29.8 No No
7 empty 1.83 75.8 20.8 No No
8 empty 1.84 71.3 22.5 No No
9 empty 1.78 62.8 20.7 No No
10 empty 1.09 62.4 20.4 No No
6MHX_A Transient receptor potential cation channel subfamily V member 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.85 71.9 50.5 Yes Yes
2 empty 1.94 67.6 47.7 No No
3 empty 1.98 64.5 30.2 No No
4 empty 1.54 73.6 31 No No
5 empty 1.35 67.4 21.1 No No
6 empty 1.86 70.6 31 No No
7 empty 1.68 68.9 23.3 No No
8 empty 1.78 65.8 19.6 No No
9 empty 1.89 64.2 25.1 No No
10 empty 1.22 63.5 25.4 No No
6MHW_B Transient receptor potential cation channel subfamily V member 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.8 69.2 62.2 Yes Yes
2 empty 1.53 65.5 27.4 No No
3 empty 1.12 69.9 23 No No
4 empty 2.02 64.9 25.9 No No
5 empty 1.78 70.6 30.1 No No
6 empty 2.38 68 19.2 No No
7 empty .89 62.7 24.2 No No
8 empty 1.85 67.7 24.6 No No
9 empty 1.94 70.9 23.8 No No
10 empty 2.42 66.9 19.5 No No
6MHW_C Transient receptor potential cation channel subfamily V member 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.89 71.5 57.8 Yes Yes
2 empty 1.45 68.1 30 No No
3 empty 1.63 63 29.6 No No
4 empty 1.8 69.9 27.9 No No
5 empty 1.93 67.9 22.3 No No
6 empty 1.78 79.9 19 No No
7 empty 2.06 61.4 24.5 No No
8 empty 1.85 66.7 28.3 No No
9 empty 1.21 62.4 20.9 No No
10 empty 1.5 62.4 25.1 No No
6OT2_A Transient receptor potential cation channel subfamily V member 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.85 71.4 40.8 Yes Yes
2 empty 1.91 68.6 50.4 No No
3 empty 1.65 63.8 51.2 No No
4 empty 1.3 68.7 25.5 No No
5 empty 1.66 66.8 23.3 No No
6 empty 1.94 72 19.8 No No
7 empty .87 63.5 24.6 No No
8 empty 1.89 72.6 17.7 No No
9 empty 2.17 67.3 16 No No
10 empty .99 65.7 13.4 No No
6MHO_D Transient receptor potential cation channel subfamily V member 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.59 72.9 40.6 Yes Yes
2 empty 1.74 61.3 30.8 No No
3 empty 1.89 67 35.6 No No
4 empty 1.37 66.5 21.5 No No
5 empty 1.95 74.5 24.8 No No
6 empty 1.94 69.3 30.1 No No
7 empty 1.4 69.3 22.8 No No
8 empty 1.76 71.5 19.7 No No
9 empty 1.11 62.2 20.4 No No
10 empty 1.51 74.8 16.7 No No
6OT5_A Transient receptor potential cation channel subfamily V member 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.75 68.8 57.6 Yes Yes
2 empty 1.51 67.8 49.8 No No
3 bound 2.06 68.4 40.4 No No
4 empty 1.3 66.1 22.5 No No
5 empty 1.93 67.3 25.7 No No
6 empty 2.04 68.3 15.1 No No
7 empty 2.1 66.7 17.6 No No
8 empty 1.71 63.7 21.2 No No
9 empty 1.53 67 16.6 No No
10 empty .89 65.3 21.7 No No
6MHS_D Transient receptor potential cation channel subfamily V member 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 71.3 42 Yes Yes
2 empty 2.06 70.3 36.6 No No
3 empty 1.99 62.2 29.8 No No
4 empty 1.5 72.6 20.4 No No
5 empty 2.22 64.6 33.1 No No
6 empty 1.94 71.3 16.9 No No
7 empty 1.84 74.8 17.9 No No
8 empty 1.56 74.6 15.2 No No
9 empty 1.75 61.7 21 No No
10 empty 1.56 58.4 24.2 No No
6OT2_C Transient receptor potential cation channel subfamily V member 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 70.2 42.3 Yes Yes
2 empty 1.85 66.1 33.9 No No
3 empty 1.93 66.6 36.1 No No
4 empty 1.76 61.3 34.3 No No
5 empty .89 69.2 29.3 No No
6 empty 1.28 69.5 24.6 No No
7 empty 1.73 66.9 25.2 No No
8 empty 1.03 65.5 20.8 No No
9 empty 1.99 72.5 19.6 No No
10 empty 2.17 68 17.7 No No
6MHS_A Transient receptor potential cation channel subfamily V member 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2 71.8 41.6 Yes Yes
2 empty 2.04 71.3 35.2 No No
3 empty 2.04 62.9 33.7 No No
4 empty 1.26 71.5 23.2 No No
5 empty 2.21 65.3 32 No No
6 empty 1.85 69.5 22.3 No No
7 empty 2.05 75 23 No No
8 empty 1.58 75.1 16 No No
9 empty 1.74 62 20.3 No No
10 empty 1.56 60.4 22.9 No No
6MHW_D Transient receptor potential cation channel subfamily V member 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.6 71 41.8 Yes Yes
2 empty 1.74 69.1 48.1 No No
3 empty 1.5 68.7 21.2 No No
4 empty 1.1 71.7 22.6 No No
5 empty 1.89 62.4 26.1 No No
6 empty 2.24 67.5 21.1 No No
7 empty 1.75 70.1 27.2 No No
8 empty 1.03 62.5 25.4 No No
9 empty 1.83 71.4 24.9 No No
10 empty 1.9 71.5 22.4 No No
6MHO_A Transient receptor potential cation channel subfamily V member 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.29 72.4 43.6 Yes Yes
2 empty 2.07 63.8 42.5 No No
3 empty 1.87 67.5 38.2 No No
4 empty 1.96 73.4 24.4 No No
5 empty 1.31 67.1 29.4 No No
6 empty 2 68.9 30.6 No No
7 empty 1.82 67.1 28.5 No No
8 empty 1.1 66.1 19.8 No No
9 empty 1.51 73.3 16.3 No No
10 empty 1.64 62.8 22.6 No No
6MHO_C Transient receptor potential cation channel subfamily V member 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.3 72.5 40.2 Yes Yes
2 empty 2.11 62.7 45 No No
3 empty 1.89 66 37.9 No No
4 empty 1.86 73.7 23.7 No No
5 empty 1.32 66.3 27.2 No No
6 empty 1.99 70.1 30.2 No No
7 empty 1.15 65.4 20 No No
8 empty 1.51 77.6 16.3 No No
9 empty 2.07 68.5 15.6 No No
10 empty 1.74 62.4 14.4 No No
6OT5_D Transient receptor potential cation channel subfamily V member 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.71 68.6 56.1 Yes Yes
2 empty 1.61 67.6 49.2 No No
3 bound 1.99 69.4 34.7 No No
4 empty 1.3 68.5 21.6 No No
5 empty 1.92 67.2 25.6 No No
6 empty 2.04 65.3 17.8 No No
7 empty 1.76 62.9 21.4 No No
8 empty .87 66.3 19.2 No No
9 empty 2 56.3 17.2 No No
10 empty 1.52 68.9 17.8 No No
6MHS_B Transient receptor potential cation channel subfamily V member 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.17 72.5 42 Yes Yes
2 empty 2.02 69.6 34.2 No No
3 empty 2.23 65 31.8 No No
4 empty 2.13 59.8 33.7 No No
5 empty 1.65 71.5 23.9 No No
6 empty 1.93 70.2 21 No No
7 empty 1.51 75.7 15.7 No No
8 empty 1.75 62.7 20.5 No No
9 empty 1.64 58.7 22.2 No No
10 empty 1.7 64.7 20 No No
6OT5_B Transient receptor potential cation channel subfamily V member 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.72 71 53.8 Yes Yes
2 empty 1.71 68.7 48.7 No No
3 bound 2.08 67.8 36.3 No No
4 empty 1.95 62.6 30.5 No No
5 empty 1.35 65.5 23 No No
6 empty 1.9 66.3 26.3 No No
7 empty 2.04 70 21.7 No No
8 empty 2.04 61.9 19.8 No No
9 empty 1.75 62.7 21.7 No No
10 empty .86 59.2 21.5 No No
6MHX_C Transient receptor potential cation channel subfamily V member 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 71.5 49.7 Yes Yes
2 empty 1.91 67.1 47.3 No No
3 empty 1.88 63.3 31.3 No No
4 empty 1.53 75.2 30.5 No No
5 empty 1.39 65.7 21.6 No No
6 empty 1.81 76.2 19.7 No No
7 empty 1.58 67.9 22.9 No No
8 empty 1.86 62.7 26.5 No No
9 empty 1.81 66.7 18.9 No No
10 empty 1.09 64.6 19.7 No No
6MHS_C Transient receptor potential cation channel subfamily V member 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.95 73 46.5 Yes Yes
2 empty 2.05 68.3 34.7 No No
3 empty 2.15 62.6 31.7 No No
4 empty 1.2 71.7 20.4 No No
5 empty 2.29 66.6 32.2 No No
6 empty 1.87 69.5 20.7 No No
7 empty 1.53 77.4 14.7 No No
8 empty 1.77 63.9 20 No No
9 empty 1.51 58.5 24 No No
10 empty 1.82 67.8 15 No No
6OT2_B Transient receptor potential cation channel subfamily V member 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.83 70.1 40.3 Yes Yes
2 empty 1.84 68.3 48.7 No No
3 empty 1.75 63.1 50.5 No No
4 empty 1.27 69.8 24.8 No No
5 empty 1.65 66.9 30.3 No No
6 empty 1.98 68.7 25.2 No No
7 empty .87 64.7 23.2 No No
8 empty 1.86 76.1 14 No No
9 empty 2.17 65.3 17.9 No No
10 empty 1.88 62.6 20.3 No No
6MHX_B Transient receptor potential cation channel subfamily V member 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.73 70.4 51.2 Yes Yes
2 empty 1.95 67.6 32.8 No No
3 empty 1.28 68.4 22 No No
4 empty 1.48 58.1 32.1 No No
5 empty 1.63 74 24 No No
6 empty 1.77 70.4 22.4 No No
7 empty 1.8 69.1 22.3 No No
8 empty 1.99 63.1 20.3 No No
9 empty 1.78 72.3 26.6 No No
10 empty 1.86 67.1 27.2 No No
6MHV_C Transient receptor potential cation channel subfamily V member 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.83 71.2 46.8 Yes Yes
2 empty 2.09 66.6 35.9 No No
3 empty 1.8 70 33.3 No No
4 empty 1.67 64.7 32.2 No No
5 empty 1.76 64 29.3 No No
6 empty 2.03 66.8 19.5 No No
7 empty 1.97 69.5 21.5 No No
8 empty 1.37 77 15.6 No No
9 empty .97 64.4 20.4 No No
10 empty 1.96 78.8 16.4 No No
Ligand-based Druggability Score: 0.2
Ligand-based Druggability Score Percentile: 82%
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score