Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TRPV3 (Q8NET8) - Overview - Molecular Target Synopsis

Protein


TRPV3, Transient receptor potential cation channel subfamily V member 3
UniProt Q8NET8

Also Known as TRPV3_HUMAN, TRPV3

Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen). May form a heteromeric channel with TRPV1. Interacts with TRPV1.

6OT2
STRUCTURE OF THE TRPV3 K169A SENSITIZED MUTANT IN APO FORM AT 4.1 A RESOLUTION
RCSB/PDB
Inspect Structure
See all 3D Structures for TRPV3

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TRPV3 is active in the following subcellular-locations: membrane.
GO terms: TRPV3 is active in the following subcellular-locations: integral component of plasma membrane, plasma membrane, receptor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TRPV3 has gain in 0 cell-lines, loss in 3 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, MOLP-2, ABC-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For TRPV3 there are:
7 structures (28 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TRPV3 has been screened with 482 compounds (518 bioactivities), 112 compounds have bioactivities that show binding affinity of <= 500nM (121 bioactivities). (see details)