Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACVR1C (Q8NER5) - Overview - Molecular Target Synopsis

Protein


ACVR1C, Activin receptor type-1C
Enzyme Classification 2.7.11.30
UniProt Q8NER5

Also Known as ACV1C_HUMAN, ACVR1C, ALK7

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. Binds the type 2 receptor protein ACVR2A.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ACVR1C is active in the following subcellular-locations: membrane.
GO terms: ACVR1C is active in the following subcellular-locations: activin receptor complex, integral component of plasma membrane, plasma membrane, receptor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACVR1C has gain in 2 cell-lines, loss in 2 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1092, NCI-H2081, NCI-H810

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


ACVR1C was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: CAL51, OS25HAL. (see details)

3D Structures


At greater than 75% identity similarity to ACVR1C there are:
32 structures (51 chains) solved
26 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ACVR1C has been screened with 14 compounds (29 bioactivities). (see details)