TRPV1 (Q8NER1) - Overview - Molecular Target Synopsis
TRPV1, Transient receptor potential cation channel subfamily V member 1
Also Known as TRPV1_HUMAN, TRPV1, VR1
Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis. Interacts with PIRT (By similarity). Homotetramer (By similarity). Interacts with TRPV3 and may also form a heteromeric channel with TRPV3 (PubMed:12077606). Interacts with CALM, PRKCM and CSK. Interacts with PRKCG and NTRK1, probably by forming a trimeric complex (By similarity). Interacts with the Scolopendra mutilans RhTx toxin (By similarity). Interacts with TMEM100 (By similarity). Interacts with PACS2 (PubMed:29656858).
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|839||ENSG00000196689, ENSG00000262304||ENST00000399759, ENST00000572705, ENST00000571088, ENST00000399756||ENSP00000382661, ENSP00000459962, ENSP00000461007, ENSP00000382659||Q8NER1-1|
UniProt: TRPV1 is active in the following subcellular-locations: cell junction, cell membrane, cell projection, dendritic spine membrane, postsynaptic cell membrane, synapse.
GO terms: TRPV1 is active in the following subcellular-locations: cell junction, cytosol, dendritic spine membrane, external side of plasma membrane, integral component of membrane, integral component of plasma membrane, intrinsic component of plasma membrane, mitochondrion, neuronal cell body, plasma membrane, postsynaptic membrane.