HIPK4, Homeodomain-interacting protein kinase 4
Enzyme Classification 18.104.22.168
Also Known as
Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors .
Isoforms / Transcripts (Protein Coding)
UniProt: HIPK4 is active in the following subcellular-locations: cytoplasm.
GO terms: HIPK4 is active in the following subcellular-locations: cytoplasm, nucleus.
Gene Copy Number Variation
In COSMIC - Cell Lines Project HIPK4 has gain in 12 cell-lines, loss in 0 cell-lines and no signal in 992 cell-lines. (see details)
In NCI60, the highest expressing cell lines are:
In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, HCC12
In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM(see details)
HIPK4 was reported in the following RNAI studies:
Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: TE10, NY. (see details)
At greater than 35% identity similarity to HIPK4 there are:
30 structures (106 chains) solved
30 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug
HIPK4 is solved in complex with the approved drug(s):
).(see details)Molecular Target 3D Synopsis
Screening and Chemistry
HIPK4 has been screened with 484 compounds (866 bioactivities), 16 compounds have bioactivities that show binding affinity of <= 500nM (20 bioactivities). (see details)