Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

SLC17A8 (Q8NDX2) - Overview - Molecular Target Synopsis


SLC17A8, Vesicular glutamate transporter 3
UniProt Q8NDX2

Also Known as VGLU3_HUMAN, SLC17A8, VGLUT3

Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: SLC17A8 is active in the following subcellular-locations: cell junction, cytoplasmic vesicle, membrane, secretory vesicle, synapse, synaptic vesicle membrane, synaptosome.
GO terms: SLC17A8 is active in the following subcellular-locations: apical dendrite, axon terminus, basal dendrite, cell junction, excitatory synapse, glial limiting end-foot, integral component of membrane, integral component of synaptic vesicle membrane, multivesicular body, pericellular basket, perikaryon, synaptic vesicle membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project SLC17A8 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-N-DZ, Hs 746T, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

Screening and Chemistry

SLC17A8 has been screened with compounds ( bioactivities). (see details)