SMC1B (Q8NDV3) - Overview - Molecular Target Synopsis
SMC1B, Structural maintenance of chromosomes protein 1B
Also Known as SMC1B_HUMAN, SMC1B, SMC1L2
Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I. Forms a heterodimer with SMC3. Component of a meiosis-specific cohesin complex, probably composed of the SMC1B and SMC3 heterodimer attached via their SMC hinge domain, RAD21 (or its meiosis-specific related protein REC8), which link them, and STAG3, which interacts with RAD21 or REC8.
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UniProt: SMC1B is active in the following subcellular-locations: centromere, chromosome, nucleus.
GO terms: SMC1B is active in the following subcellular-locations: chromosome, cytosol, lateral element, meiotic cohesin complex, nuclear meiotic cohesin complex, nucleoplasm.