Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PPFIBP2 (Q8ND30) - Overview - Molecular Target Synopsis

Protein


PPFIBP2, Liprin-beta-2
UniProt Q8ND30

Also Known as LIPB2_HUMAN, PPFIBP2

May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. Forms homodimers and heterodimers (PubMed:21462929).

3QH9
HUMAN LIPRIN-BETA2 COILED-COIL
RCSB/PDB
Inspect Structure
See all 3D Structures for PPFIBP2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: PPFIBP2 is active in the following subcellular-locations: cytosol, extracellular space, intracellular, presynapse.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PPFIBP2 has gain in 0 cell-lines, loss in 3 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_28, HCC_2998, IGROV1

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: RT4, NCI-H520, MHH-PREB-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HMEC

(see details)

3D Structures


For PPFIBP2 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis