Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC16A11 (Q8NCK7) - Overview - Molecular Target Synopsis

Protein


SLC16A11, Monocarboxylate transporter 11
UniProt Q8NCK7

Also Known as MOT11_HUMAN, SLC16A11, MCT11

Proton-linked monocarboxylate transporter. It catalyzes the transport of pyruvate across the plasma membrane (PubMed:28666119). Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids (PubMed:24390345). Interacts with BSG.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLC16A11 is active in the following subcellular-locations: cell membrane, endoplasmic reticulum membrane.
GO terms: SLC16A11 is active in the following subcellular-locations: endoplasmic reticulum membrane, integral component of plasma membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC16A11 has gain in 2 cell-lines, loss in 4 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: 786_0, MOLT_4, ACHN

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, SK-N-FI, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)


Screening and Chemistry


SLC16A11 has been screened with compounds ( bioactivities). (see details)