Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

DAGLB (Q8NCG7) - Overview - Molecular Target Synopsis

Protein


DAGLB, Sn1-specific diacylglycerol lipase beta
Enzyme Classification 3.1.1.-
UniProt Q8NCG7

Also Known as DGLB_HUMAN, DAGLB

Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: DAGLB is active in the following subcellular-locations: cell membrane.
GO terms: DAGLB is active in the following subcellular-locations: integral component of membrane, lysosomal membrane, nucleus, plasma membrane, postsynaptic membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project DAGLB has gain in 5 cell-lines, loss in 1 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H226, BT_549, NCI_ADR_RES

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: BICR 31, SUP-B15, NCI-H226

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HeLa-S3, BJ

(see details)


Screening and Chemistry


DAGLB has been screened with 11 compounds (15 bioactivities), 7 compounds have bioactivities that show binding affinity of <= 500nM (8 bioactivities). (see details)