Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NFATC2IP (Q8NCF5) - Overview - Molecular Target Synopsis

Protein


NFATC2IP, NFATC2-interacting protein
UniProt Q8NCF5

Also Known as NF2IP_HUMAN, NFATC2IP, NIP45

In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9. Interacts with NFATC2, TRAF1, TRAF2 and PRMT1. Interacts with UBE2I/UBC9.

3RD2
NIP45 SUMO-LIKE DOMAIN 2
RCSB/PDB
Inspect Structure
See all 3D Structures for NFATC2IP

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: NFATC2IP is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: NFATC2IP is active in the following subcellular-locations: cytoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NFATC2IP has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SN12C, CCRF_CEM, UO_31

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1155, HCC366, BICR 31

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, HMEC

(see details)

3D Structures


For NFATC2IP there are:
3 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis