Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PLA2G15 (Q8NCC3) - Overview - Molecular Target Synopsis

Protein


PLA2G15, Group XV phospholipase A2
Enzyme Classification 2.3.1.-
UniProt Q8NCC3

Also Known as PAG15_HUMAN, PLA2G15, LYPLA3

Has transacylase and calcium-independent phospholipase A2 activity (PubMed:20410020, PubMed:23958596). Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid (PubMed:11790796, PubMed:25727495). Has high activity with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), catalyzing the transfer of oleic acid to N-acetyl-sphingosine. Required for normal phospholipid degradation in alveolar and peritoneal macrophages and in spleen (By similarity). May have weak lysophospholipase activity (PubMed:10092508).

6MTW
LYSOSOMAL PHOSPHOLIPASE A2 IN COMPLEX WITH ZINC
RCSB/PDB
Inspect Structure
See all 3D Structures for PLA2G15

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PLA2G15 is active in the following subcellular-locations: lysosome, membrane, secreted.
GO terms: PLA2G15 is active in the following subcellular-locations: extracellular exosome, extracellular region, extracellular space, intracellular membrane-bounded organelle, lysosome, membrane, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PLA2G15 has gain in 1 cell-lines, loss in 3 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RPMI_8226, CAKI_1, UO_31

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 255.T, SiHa, Hs 895.T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HUVEC, IMR-90

(see details)

3D Structures


For PLA2G15 there are:
8 structures (20 chains) solved
8 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PLA2G15 has been screened with 3 compounds (3 bioactivities). (see details)