Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CAMKV (Q8NCB2) - Overview - Molecular Target Synopsis

Protein


CAMKV, CaM kinase-like vesicle-associated protein
UniProt Q8NCB2

Also Known as CAMKV_HUMAN, CAMKV

Does not appear to have detectable kinase activity. Interacts with calmodulin, in the presence of calcium.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: CAMKV is active in the following subcellular-locations: cell membrane, cytoplasmic vesicle membrane.
GO terms: CAMKV is active in the following subcellular-locations: cytoplasmic vesicle membrane, glutamatergic synapse, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CAMKV has gain in 0 cell-lines, loss in 7 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: PC_3, HOP_92, MOLT_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KELLY, NCI-H82, NCI-H847

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


CAMKV was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: SCC90, HS578T. (see details)

3D Structures


At greater than 35% identity similarity to CAMKV there are:
84 structures (127 chains) solved
71 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

CAMKV is solved in complex with the approved drug(s):

B49/SUNITINIB (2Y7J_A, 2Y7J_B, 2Y7J_C, 2Y7J_D),
DB8/BOSUTINIB (3SOA_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CAMKV has been screened with compounds ( bioactivities). (see details)