Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

CAMKV (Q8NCB2) - Overview - Molecular Target Synopsis


CAMKV, CaM kinase-like vesicle-associated protein
UniProt Q8NCB2


Does not appear to have detectable kinase activity. Interacts with calmodulin, in the presence of calcium.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: CAMKV is active in the following subcellular-locations: cell membrane, cytoplasmic vesicle membrane.
GO terms: CAMKV is active in the following subcellular-locations: cytoplasmic vesicle membrane, glutamatergic synapse, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project CAMKV has gain in 0 cell-lines, loss in 7 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: PC_3, HOP_92, MOLT_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KELLY, NCI-H82, NCI-H847

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference

CAMKV was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: SCC90, HS578T. (see details)

3D Structures

At greater than 35% identity similarity to CAMKV there are:
84 structures (127 chains) solved
71 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

CAMKV is solved in complex with the approved drug(s):

B49/SUNITINIB (2Y7J_A, 2Y7J_B, 2Y7J_C, 2Y7J_D),

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

CAMKV has been screened with compounds ( bioactivities). (see details)