Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RELL2 (Q8NC24) - Overview - Molecular Target Synopsis

Protein


RELL2, RELT-like protein 2
UniProt Q8NC24

Also Known as RELL2_HUMAN, RELL2, C5orf16

Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290). Interacts with RELT, RELL1 and OXSR1 (PubMed:16389068). Interacts with PLSCR1 (PubMed:22052202). Interacts with TRAF2 (PubMed:19969290).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RELL2 is active in the following subcellular-locations: cell membrane.
GO terms: RELL2 is active in the following subcellular-locations: basement membrane, integral component of membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RELL2 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HEL, DMS 53, SUM 52PE

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, HSMM

(see details)