Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

UXS1 (Q8NBZ7) - Overview - Molecular Target Synopsis

Protein


UXS1, UDP-glucuronic acid decarboxylase 1
Enzyme Classification 4.1.1.35
UniProt Q8NBZ7

Also Known as UXS1_HUMAN, UXS1

Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis. Interacts with AKT1.

4M55
CRYSTAL STRUCTURE OF HUMAN UDP-XYLOSE SYNTHASE R236H SUBSTITUTION
RCSB/PDB
Inspect Structure
See all 3D Structures for UXS1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: UXS1 is active in the following subcellular-locations: golgi apparatus, golgi stack membrane.
GO terms: UXS1 is active in the following subcellular-locations: cytoplasm, extracellular exosome, Golgi cisterna membrane, integral component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project UXS1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 1005 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: ACHN, SK_MEL_28, OVCAR_8

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OVMANA, OVISE, ACHN

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, NHLF, HMEC

(see details)

3D Structures


For UXS1 there are:
4 structures (15 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis