Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

CSNK1A1L (Q8N752) - Overview - Molecular Target Synopsis


CSNK1A1L, Casein kinase I isoform alpha-like
Enzyme Classification
UniProt Q8N752

Also Known as KC1AL_HUMAN, CSNK1A1L

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: CSNK1A1L is active in the following subcellular-locations: cytoplasm.
GO terms: CSNK1A1L is active in the following subcellular-locations: cytoplasm, cytosol, nucleus.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project CSNK1A1L has gain in 2 cell-lines, loss in 5 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference

CSNK1A1L was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: OAW42, BXPC3. (see details)

3D Structures

At greater than 90% identity similarity to CSNK1A1L there are:
2 structures (3 chains) solved
1 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

CSNK1A1L has been screened with 105 compounds (137 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (2 bioactivities). (see details)