Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CSNK1A1L (Q8N752) - Overview - Molecular Target Synopsis

Protein


CSNK1A1L, Casein kinase I isoform alpha-like
Enzyme Classification 2.7.11.1
UniProt Q8N752

Also Known as KC1AL_HUMAN, CSNK1A1L

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
473ENSG00000180138ENST00000379800ENSP00000369126
337Q8N752-1

Sub-cellular localization


UniProt: CSNK1A1L is active in the following subcellular-locations: cytoplasm.
GO terms: CSNK1A1L is active in the following subcellular-locations: cytoplasm, cytosol, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CSNK1A1L has gain in 2 cell-lines, loss in 5 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


CSNK1A1L was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: OAW42, BXPC3. (see details)

3D Structures


At greater than 90% identity similarity to CSNK1A1L there are:
2 structures (3 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CSNK1A1L has been screened with 105 compounds (137 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (2 bioactivities). (see details)