Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ARFGAP1 (Q8N6T3) - Overview - Molecular Target Synopsis

Protein


ARFGAP1, ADP-ribosylation factor GTPase-activating protein 1
UniProt Q8N6T3

Also Known as ARFG1_HUMAN, ARFGAP1, ARF1GAP

GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Interacts with ARF1. Interacts with the COPI coat proteins, KDELR1 and TMED2. The interaction with TMED2 inhibits the GAP activity.

3O47
CRYSTAL STRUCTURE OF ARFGAP1-ARF1 FUSION PROTEIN
RCSB/PDB
Inspect Structure
See all 3D Structures for ARFGAP1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ARFGAP1 is active in the following subcellular-locations: cytoplasm, golgi apparatus.
GO terms: ARFGAP1 is active in the following subcellular-locations: cytosol, Golgi membrane, postsynaptic density, synapse.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ARFGAP1 has gain in 6 cell-lines, loss in 1 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MOLT_4, SR, SK_MEL_28

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK23, SNU-182, G84

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, IMR-90

(see details)

3D Structures


For ARFGAP1 there are:
2 structures (4 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis