Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

IL22RA1 (Q8N6P7) - Overview - Molecular Target Synopsis

Protein


IL22RA1, Interleukin-22 receptor subunit alpha-1
UniProt Q8N6P7

Also Known as I22R1_HUMAN, IL22RA1, IL22R

Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. Heterodimer with IL10RB and with IL20RB. IL22 binding to heterodimer is greater than binding to IL22RA1 alone.

6DF3
CRYSTAL STRUCTURE OF TERNARY COMPLEX OF IL-24 WITH SOLUBLE RECEPTORS IL-22RA AND IL-20RB
RCSB/PDB
Inspect Structure
See all 3D Structures for IL22RA1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
574ENSG00000142677ENST00000270800ENSP00000270800Q8N6P7-1

Sub-cellular localization


UniProt: IL22RA1 is active in the following subcellular-locations: membrane.
GO terms: IL22RA1 is active in the following subcellular-locations: integral component of membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project IL22RA1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 1005 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: KM12, COLO205, HT29

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HT-29, SNU-C1, PK-59

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For IL22RA1 there are:
3 structures (4 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis