Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MEIOB (Q8N635) - Overview - Molecular Target Synopsis

Protein


MEIOB, Meiosis-specific with OB domain-containing protein
Enzyme Classification 3.1.-.-
UniProt Q8N635

Also Known as MEIOB_HUMAN, MEIOB, C16orf73

Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro. Component of a multiprotein complex with RPA2 and SPATA22.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MEIOB is active in the following subcellular-locations: chromosome, cytoplasm, nucleus.
GO terms: MEIOB is active in the following subcellular-locations: chromosome, cytoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MEIOB has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC1534, NCI-H187, NCI-H82

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, SK-N-SH, NHLF

(see details)