MEIOB (Q8N635) - Overview - Molecular Target Synopsis
MEIOB, Meiosis-specific with OB domain-containing protein
Enzyme Classification 3.1.-.-
Also Known as MEIOB_HUMAN, MEIOB, C16orf73
Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro. Component of a multiprotein complex with RPA2 and SPATA22.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|471||ENSG00000162039||ENST00000325962, ENST00000412554||ENSP00000314484, ENSP00000390778||Q8N635-2|
UniProt: MEIOB is active in the following subcellular-locations: chromosome, cytoplasm, nucleus.
GO terms: MEIOB is active in the following subcellular-locations: chromosome, cytoplasm, nucleus.