Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

AADAT (Q8N5Z0) - Overview - Molecular Target Synopsis

Protein


AADAT, Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Enzyme Classification 2.6.1.39
UniProt Q8N5Z0

Also Known as AADAT_HUMAN, AADAT, KAT2

Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro). Homodimer.

6D0A
CRYSTAL STRUCTURE OF KYNURENINE AMINOTRANSFERASE-II IN APO-FORM, AT 1.47 A RESOLUTION
RCSB/PDB
Inspect Structure
See all 3D Structures for AADAT

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: AADAT is active in the following subcellular-locations: mitochondrion.
GO terms: AADAT is active in the following subcellular-locations: mitochondrial matrix.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project AADAT has gain in 0 cell-lines, loss in 7 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HCC_2998, MDA_MB_435, SW_620

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: LNCAP, UKE-1, MDA-MB-134-VI

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, AG445, MCF-7

(see details)

3D Structures


For AADAT there are:
15 structures (35 chains) solved
13 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


AADAT has been screened with 67 compounds (178 bioactivities), 53 compounds have bioactivities that show binding affinity of <= 500nM (107 bioactivities). (see details)