Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RFLNB (Q8N5W9) - Overview - Molecular Target Synopsis

Protein


RFLNB, Refilin-B
UniProt Q8N5W9

Also Known as RFLB_HUMAN, RFLNB

Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements. Interacts with FLNA and FLNB.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
214Q8N5W9-1
144ENSG00000183688ENST00000329099ENSP00000331915

Sub-cellular localization


UniProt: RFLNB is active in the following subcellular-locations: cytoplasm, cytoskeleton.
GO terms: RFLNB is active in the following subcellular-locations: actin filament bundle, cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RFLNB has gain in 1 cell-lines, loss in 7 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are:

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are:

(see details)