Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CAMKK1 (Q8N5S9) - Overview - Molecular Target Synopsis

Protein


CAMKK1, Calcium/calmodulin-dependent protein kinase kinase 1
Enzyme Classification 2.7.11.17
UniProt Q8N5S9

Also Known as KKCC1_HUMAN, CAMKK1, CAMKKA

Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. Interacts with CAMK4 and calmodulin.

6CCF
CRYSTAL STRUCTURE OF THE HUMAN CAMKK1A IN COMPLEX WITH HESPERADIN
RCSB/PDB
Inspect Structure
See all 3D Structures for CAMKK1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: CAMKK1 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: CAMKK1 is active in the following subcellular-locations: cytoplasm, cytosol, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CAMKK1 has gain in 0 cell-lines, loss in 4 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: CAKI_1, 786_0, HT29

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H82, G84, NCI-H2171

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HeLa-S3, A549

(see details)

RNA Interference


CAMKK1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: DU4475, HCC202. (see details)

3D Structures


For CAMKK1 there are:
2 structures (6 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CAMKK1 has been screened with 193 compounds (273 bioactivities), 11 compounds have bioactivities that show binding affinity of <= 500nM (21 bioactivities). (see details)