Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MRPL50 (Q8N5N7) - Overview - Molecular Target Synopsis

Protein


MRPL50, 39S ribosomal protein L50, mitochondrial
UniProt Q8N5N7

Also Known as RM50_HUMAN, MRPL50

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:25278503, PubMed:25838379, PubMed:28892042). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

5OOL
STRUCTURE OF A NATIVE ASSEMBLY INTERMEDIATE OF THE HUMAN MITOCHONDRIAL RIBOSOME WITH UNFOLDED INTERFACIAL RRNA
RCSB/PDB
Inspect Structure
See all 3D Structures for MRPL50

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
158ENSG00000136897ENST00000374865ENSP00000363999Q8N5N7-1
135ENSG00000136897ENST00000539624ENSP00000443844Q8N5N7-2

Sub-cellular localization


UniProt: MRPL50 is active in the following subcellular-locations: mitochondrion.
GO terms: MRPL50 is active in the following subcellular-locations: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MRPL50 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, NCI_H460, K_562

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hep G2, KYSE-150, A-375

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, MCF-7, HSMM

(see details)

3D Structures


For MRPL50 there are:
3 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis