Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

OXR1 (Q8N573) - Overview - Molecular Target Synopsis

Protein


OXR1, Oxidation resistance protein 1
UniProt Q8N573

Also Known as OXR1_HUMAN, OXR1

May be involved in protection from oxidative damage.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: OXR1 is active in the following subcellular-locations: mitochondrion.
GO terms: OXR1 is active in the following subcellular-locations: intracellular membrane-bounded organelle, mitochondrion, nucleolus, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project OXR1 has gain in 24 cell-lines, loss in 2 cell-lines and no signal in 979 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SW_620, HT29, OVCAR_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-398, SW 48, EFM-192C

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, MCF-7, AG445

(see details)

3D Structures


At greater than 75% identity similarity to OXR1 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis