DCLK2 (Q8N568) - Overview - Molecular Target Synopsis
DCLK2, Serine/threonine-protein kinase DCLK2
Enzyme Classification 18.104.22.168
Also Known as DCLK2_HUMAN, DCLK2, DCAMKL2, DCDC3B, DCK2
Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm. Binds to and stabilizes microtubules. Interacts with MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK9/JNK2, PPP1R9B/NEURABIN-2 and actin.
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UniProt: DCLK2 is active in the following subcellular-locations: cytoplasm, cytoskeleton.
GO terms: DCLK2 is active in the following subcellular-locations: cytoplasm, microtubule.