Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB42 (Q8N4Z0) - Overview - Molecular Target Synopsis

Protein


RAB42, Ras-related protein Rab-42
UniProt Q8N4Z0

Also Known as RAB42_HUMAN, RAB42

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
143ENSG00000188060ENST00000373826ENSP00000362932
105Q8N4Z0-1

Sub-cellular localization


UniProt: RAB42 is active in the following subcellular-locations: membrane.
GO terms: RAB42 is active in the following subcellular-locations: membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB42 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 1005 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC89, C3A, SUM 229PE

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HepG2, SK-N-SH, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to RAB42 there are:
107 structures (228 chains) solved
95 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

RAB42 is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (3NKV_A, 3NKV_B).

(see details)
Molecular Target 3D Synopsis