Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ARL14 (Q8N4G2) - Overview - Molecular Target Synopsis

Protein


ARL14, ADP-ribosylation factor-like protein 14
UniProt Q8N4G2

Also Known as ARL14_HUMAN, ARL14, ARF7

GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. Interacts with ARL14EP.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
256ENSG00000179674ENST00000320767ENSP00000323847
192Q8N4G2-1

Sub-cellular localization


UniProt: ARL14 is active in the following subcellular-locations: cytoplasmic vesicle.
GO terms: ARL14 is active in the following subcellular-locations: cytoplasm, cytoplasmic vesicle, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ARL14 has gain in 11 cell-lines, loss in 0 cell-lines and no signal in 994 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HOP_62, NCI_H322M, HT29

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC366, CAL-85-1, Calu-3

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to ARL14 there are:
88 structures (186 chains) solved
77 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ARL14 has been screened with compounds ( bioactivities). (see details)