Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MINK1 (Q8N4C8) - Overview - Molecular Target Synopsis

Protein


MINK1, Misshapen-like kinase 1
Enzyme Classification 2.7.11.1
UniProt Q8N4C8

Also Known as MINK1_HUMAN, MINK1, B55, MAP4K6, MINK, YSK2, ZC3

Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1., Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. Interacts with TANC1 (By similarity). Interacts with RAP2A. Isoform 4 interacts with NCK1.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MINK1 is active in the following subcellular-locations: axon, cell junction, cell projection, cytoplasm, dendrite, golgi apparatus, postsynaptic cell membrane, postsynaptic density, synapse.
GO terms: MINK1 is active in the following subcellular-locations: axon, cell junction, cytoplasm, cytosol, dendrite, extracellular exosome, Golgi apparatus, postsynaptic density, postsynaptic membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MINK1 has gain in 0 cell-lines, loss in 6 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HCC_2998, M14, BT_549

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HT-55, MS751, NCI-H82

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HMEC, A549

(see details)

RNA Interference


MINK1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: CAL51, SKGT4. (see details)

3D Structures


At greater than 90% identity similarity to MINK1 there are:
20 structures (43 chains) solved
18 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MINK1 has been screened with 719 compounds (1284 bioactivities), 22 compounds have bioactivities that show binding affinity of <= 500nM (28 bioactivities). (see details)