Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GPD1L (Q8N335) - Overview - Molecular Target Synopsis

Protein


GPD1L, Glycerol-3-phosphate dehydrogenase 1-like protein
Enzyme Classification 1.1.1.8
UniProt Q8N335

Also Known as GPD1L_HUMAN, GPD1L, KIAA0089

Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L. Interacts with SCN5A.

2PLA
CRYSTAL STRUCTURE OF HUMAN GLYCEROL-3-PHOSPHATE DEHYDROGENASE 1-LIKE PROTEIN
RCSB/PDB
Inspect Structure
See all 3D Structures for GPD1L

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: GPD1L is active in the following subcellular-locations: cytoplasm.
GO terms: GPD1L is active in the following subcellular-locations: cytosol, extracellular exosome, glycerol-3-phosphate dehydrogenase complex, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GPD1L has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: PC_3, SNB_19, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: RT4, MFM-223, MDA-MB-453

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: MCF-7, HeLa-S3, HSMM

(see details)

3D Structures


For GPD1L there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GPD1L has been screened with compounds ( bioactivities). (see details)