Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

UBE2J2 (Q8N2K1) - Overview - Molecular Target Synopsis

Protein


UBE2J2, Ubiquitin-conjugating enzyme E2 J2
Enzyme Classification 2.3.2.23
UniProt Q8N2K1

Also Known as UB2J2_HUMAN, UBE2J2, NCUBE2

Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).

2F4W
HUMAN UBIQUITIN-CONJUGATING ENZYME E2 J2
RCSB/PDB
Inspect Structure
See all 3D Structures for UBE2J2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: UBE2J2 is active in the following subcellular-locations: endoplasmic reticulum membrane.
GO terms: UBE2J2 is active in the following subcellular-locations: endoplasmic reticulum, endoplasmic reticulum membrane, integral component of membrane, ubiquitin ligase complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project UBE2J2 has gain in 2 cell-lines, loss in 2 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: OVCAR_3, K_562, SN12C

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC33, BFTC-909, DMS 454

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, IMR-90, A549

(see details)

3D Structures


For UBE2J2 there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis