Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

STK40 (Q8N2I9) - Overview - Molecular Target Synopsis

Protein


STK40, Serine/threonine-protein kinase 40
Enzyme Classification 2.7.11.1
UniProt Q8N2I9

Also Known as STK40_HUMAN, STK40, SGK495, SHIK

May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.

5L2Q
SERINE/THREONINE-PROTEIN KINASE 40 (STK40) KINASE HOMOLOGY DOMAIN
RCSB/PDB
Inspect Structure
See all 3D Structures for STK40

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: STK40 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: STK40 is active in the following subcellular-locations: cytosol, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project STK40 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, MDA_MB_231, NCI_H226

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HEL, VMRC-LCD, TYK-nu

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, IMR-90, K562

(see details)

RNA Interference


STK40 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: H1650, MDAMB134VI. (see details)

3D Structures


For STK40 there are:
1 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


STK40 has been screened with compounds ( bioactivities). (see details)