Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PDIK1L (Q8N165) - Overview - Molecular Target Synopsis

Protein


PDIK1L, Serine/threonine-protein kinase PDIK1L
Enzyme Classification 2.7.11.1
UniProt Q8N165

Also Known as PDK1L_HUMAN, PDIK1L, CLIK1L

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
341ENSG00000175087ENST00000374271, ENST00000374269ENSP00000363389, ENSP00000363387Q8N165-1
191ENSG00000175087ENST00000444713ENSP00000406510

Sub-cellular localization


UniProt: PDIK1L is active in the following subcellular-locations: nucleus.
GO terms: PDIK1L is active in the following subcellular-locations: nucleoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PDIK1L has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, MOLT_4, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DMS 79, OCI-M1, MOLM-16

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: MCF-7, SK-N-SH, NHLF

(see details)

RNA Interference


PDIK1L was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: NOS1, PL5. (see details)


Screening and Chemistry


PDIK1L has been screened with compounds ( bioactivities). (see details)